With these tips, you should able to drastically increase your polygon-count limitation while sculpting.
1. Get Blender 2.5 Alpha, also go for the 64bit version if you have 3GB or more of RAM. 2.5 is simply a lot faster and refined than Blender 2.49. The tools and interface is also much cleaner and more intuitive. Also, a lot of work has gone into optimizing the sculpting feature in Blender 2.5.
2. Start with a base mesh, then apply the multires modifier. Do not use a default cube and rely on the multires modifier to do *all* the sub-division. It’s always better to start with a base mesh with a few thousand polygons, and use multires with a sub-division level of 2-5.
3. Turn off “Double Sided” in the Object Data panel. This will significantly speed up the redraw.
4. Delete UV texture data and Vertex Color data *might* help speed things up, but I don’t really know for sure.
5. Turn on VBO in the Preference menu. This will further speed up drawing speed. (Thanks Gustav!) Okay apparently it doesn’t according to another commenter, since sculpt mode already uses VBO by default.



